The oxidative stress in cattle and methods of it prevention
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StatusThe thesis was presented on the 8 July, 2015Approved by NCAA on the 7 October, 2015 Abstract – 2.45 Mb / in romanianThesisCZU 619:616–092.19–084:636.2
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Keywords
oxidative stress, antioxidant statute, peroxidation syndrome, ketosis, Diludin, mineral and vitamin premix, BioplexSummary
The structure of the thesis: introduction, five chapters, generalization of obtained results, main conclusion and recommendations; 142 pages of main text with 44 charts and 49 pictures; bibliography of 194 sources; 4 annexes. The results of the study were publish in 14 scientific works.
Fields of study:Veterinary therapy, pharmacology and toxicology.
Aim of the work: Studying the antioxidant system in cattle according on the physiological status and age of the animals (cows in transition and onset of lactation; calves), elucidating the role of oxidative stress in the pathogenesis of some morbid condition (ketosis, LMS), and approval of complexes measures to optimize antioxidant status of cows and calves.
Objectives of the study: a) to study in healthy cows (transition period and in early lactation) and calves antioxidant status particularities, and elucidate risk factors in destabilizing the balance "redox" b) study the possible involvement of oxidative stress in the pathogenesis of ketosis and lipids mobilization syndrome in cows; c) developing and testing ways to optimize antioxidant status in cows and calves, by using natural and synthetic antioxidants.
Scientific novelty and originality: experimentally we obtained rezults about the dynamics of the antioxidant status of the cows in the transition period and early lactation and described the clinical, hematological, biochemical and pathological aspects of the "peroxidation syndrome" as a manifestation of oxidative stress in cows with ketosis.
The importance of solving scientific problems: in revealing the role of the antioxidant system in the maintenance of "redox" homeostasis in calves, and cows in the transition period and early lactation, scientific argumentation for the involvement of oxidative stress in the pathogenesis of ketosis and lipids mobilization syndrome in cows, which led to the development and approval of complex measures to optimized antioxidant status, by using bioelements Se, Cu, Zn, Mn, Co, vitamins E and A, methionine and synthetic antioxidant diludin, in order to maintain health and high productivity.
Theoretical knowledge: studying the features of the antioxidant system in calves and cows in the transition period and early lactation and identification the risk factors of oxidative stress in cattle.
Applied importance: developing and testing the complex measures to optimize the antioxidant status by using bioelements Se, Cu, Zn, Mn, Co, vitamins E and A, methionine and synthetic antioxidant diludin. Introduction of the results: using as teaching material in studying chosen subjects of "Pathophysiology", "Clinical Biochemistry" and "Nutritional and metabolic diseases", included in the curricula of the Faculty of Veterinary Medicine.
Oficial Reviewers
- Valentin Gudumac
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova - Mihai Popovici
doctor habilitat, professor, Medical-Sanitary Public Institution Institute of Cardiology
Council's Members
- Vasile Macari, president
doctor habilitat, professor, Agrarian State University of Moldova - Ion Balan, secretary
doctor habilitat, associate professor (docent) - Gheorghe Boronciuc, member
doctor habilitat, professor, Institute of Physiology and Sanacreatology of the ASM - Vasile Lutan, member
doctor habilitat, professor, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova - Sava Bălănescu , member
doctor, associate professor (docent)
Theses
